July 24, 2014
IGF-1 - the Insulin-like Growth Factor 1

Your body’s GH levels are tightly regulated by numerous chemical messengers including macronutrients, neurotransmitters, and hormones. The signal to increase your body’s GH levels starts in the hypothalamus. There, two peptide hormones act in concert to increase or decrease GH output from the pituitary gland. These hormones are somatostatin (SS) and growth hormone-releasing hormone (GHRH). Somatostatin acts at the pituitary to decrease GH output. GHRH acts at the pituitary to increase GH output. Together these hormones regulate, in pulsatile fashion, the level of GH you have floating around in your body.

Several factors can effect this delicate balance. First, GH is subject to negative feedback in response to its own release. GH, as well as IGF-1, circulate back to the hypothalamus and pituitary to increase SS release, thereby decreasing GH release. GH may also act in an autocrine and paracrine fashion within both the hypothalamus and pituitary. Neurotransmitters also effect GH levels at the hypothalamus. This neuroendocrine control is still being elucidated but some factors are already clearly involved.

Growth Hormone: How does it work?

It is always prudent to have a basic understanding of how a supplement, hormone or drug works to build and/or preserve muscle before considering its use. The knowledge of how a hormone acts in the body is necessary to make your own decisions and manage your own regimens if you plan on utilizing it. Without this understanding you will no doubt end up wasting a lot of money and perhaps put your health at risk.

It has been long believed that GH exerts its anabolic effects on peripheral tissues through IGFs, also known as somatomedins (“mediator of growth”). Binding proteins play an important role in moderating the anabolic effects of both GH and IGF-1. IGF-1 is controlled by at least 6 different binding proteins and there may others waiting to be elucidated. To date there are a couple theories as to just how GH causes growth in target tissues. The first theory is called the somatomedin hypothesis.

The Somatomedin hypothesis states that GH is released from the pituitary and then travels to the liver and other peripheral tissues where it causes the synthesis and release of IGFs. IGFs got there name because of there structural and functional similarity to proinsulin. This hypothesis dictates that IGFs work as endocrine growth factors, meaning that they travel in the blood to the target tissues after being released from cells that produced it, specifically the liver in this case. Indeed, many studies have followed showing that in animals that are GH deficient, systemic IGF-1 infusions lead to normal growth. The effects were similar to those observed after GH administration. Interestingly, additional studies also followed that showed IGF-1 to be greatly inferior as an endocrine growth factor requiring almost 50 times the amount to exert that same effects of GH. Recently rhIGF-1 has become widely more available and is currently approved form the treatment of HIV associated wasting. This increased availability allowed testing of this hypothesis in humans. Studies in human subjects with GH insensitivity (Laron syndrome) has consistently validated the somatomedin hypothesis.

The second theory as to how GH produces anabolic effects is called the Dual Effector theory. This theory states that GH itself has anabolic effects on body tissues without the need of IGF-1. This theory has been supported by studies injecting GH directly into growth plates. Further evidence supporting this theory lies in genetically altered strains of mice. When comparing mice who genetically over express GH and mice who over express IGF-1, GH mice are larger. This evidence has been sited by some to support the dual effector theory. Interestingly, when IGF-1 antiserum (it destroys IGF-1) is administered concomitantly with GH, all of the anabolic effects of GH are abolished.

The Somatomedin theory and the Dual Effector theory are not all that different. One simply asserts that GH can produce growth without IGF-1. From the research I am inclined to believe in the Somatomedin theory. This only becomes an issue when one decides whether or not to use just GH or to combine it with IGF-1 or insulin.

From the evidence currently available you can count on three major mechanisms by which GH leads to growth.

The effects of GH one bone formation and organ growth are mediated by the endocrine action of IGF-1. As stated in the Somatomedin hypothesis, GH, released from the pituitary, causes increased production and release of IGF-1 into the general circulation. IGF-1 then travels to target tissues such as bones, organs, and muscle to cause anabolic effects. GH regulates the activity of IGF-1 by increasing the production of binding proteins (specifically IGFBP-3 and another important protein called the acid-labile subunit) that increase the half-life of IGF-1 from minutes to hours. Circulating proteases then act to break up the binding protein/hormone complex thereby releasing the IGF-1 in a controlled fashion over time. GH may even cause target tissues to produce IGFBP-3 increasing its effectiveness locally. IGF-1 not only has endocrine actions, but also paracrine/autocrine actions in target tissues. This means that as GH travels to my muscles, the muscle cells increase there production of IGF-1. This IGF-1 may then travel to adjacent cells (especially satellite cells) leading to growth and enhanced rejuvenative ability of cells that didn’t see any GH. This is as suggested by the Dual Effector theory.

IGF-1: How does it work?

To understand how IGF-1 works you have to understand how muscles grow. The ability of muscle tissue to constantly regenerate in response to activity makes it unique. It’s ability to respond to physical/mechanical stimuli depends greatly on what are called satellite cells. Satellite cells are muscle precursor cells. You might think of them as “pro-muscle” cells. They are cells that reside on and around muscle cells. These cells sit dormant until called upon by growth factors such as IGF-1. Once this happens these cells divide and genetically change into cells that have nuclei identical to those of muscle cells. These new satellite cells with muscle nuclei are critical if not mandatory to muscle growth.

Without the ability to increase the number of nuclei, a muscle cell will not grow larger and its ability to repair itself is limited. The explanation for this is quite simple. The nucleus of the cell is where all of the blue prints for new muscle come from. The larger the muscle, the more nuclei you need to maintain it. In fact there is a “nuclear to volume” ratio that cannot be overridden. Whenever a muscle grows in response to functional overload there is a positive correlation between the increase in the number of myonuclei and the increase in fiber cross sectional area (CSA). When satellite cells are prohibited from donating new nuclei, overloaded muscle will not grow. So you see, one important key to unnatural muscle growth is the activation of satellite cells by growth factors such as IGF-1.

IGF-1 stimulates both proliferation (an increase in cell number) and differentiation (a conversion to muscle specific nuclei) in an autocrine-paracrine manner, although it induces differentiation to a much greater degree. This is in agreement with the Dual Effector theory. In fact, you can inject a muscle with IGF-1 and it will grow! Studies have shown that , when injected locally, IGF-1 increases satellite cell activity, muscle DNA content, muscle protein content, muscle weight and muscle cross sectional area.

On the very cutting edge of research scientists are now discovering the signaling pathway by which mechanical stimulation and IGF-1 activity leads to all of the above changes in satellite cells, muscle DNA content, muscle protein content, muscle weight and muscle cross sectional area just outlined above. This research is stemming from studies done to explain cardiac hypertrophy. It involves a muscle enzyme called calcineurin which is a phosphatase enzyme activated by high intracellular calcium ion concentrations (Dunn, 1999). Note that overloaded muscle is characterized by chronically elevated intracellular calcium ion concentrations. Other recent research has demonstrated that IGF-1 increases intracellular calcium ion concentrations leading to the activation of the signaling pathway, and subsequent muscle fiber hypertrophy. I am by no means a geneticist so I hesitated even bringing this new research up. In summary the researchers involved in these studies have explained it this way, IGF-1 as well as activated calcineurin, induces expression of the transcription factor GATA-2, which accumulates in a subset of myocyte nuclei, where it associates with calcineurin and a specific dephosphorylated isoform of the transcription factor nuclear factor of activated T cells or NF-ATc1. Thus, IGF-1 induces calcineurin-mediated signaling and activation of GATA-2, a marker of skeletal muscle hypertrophy, which cooperates with selected NF-ATc isoforms to activate gene expression programs leading to increased contractile protein synthesis and muscle hypertrophy. Did you get all that?

In this the first part of “Growing beyond what nature intended” we have discussed the role, function and interaction of growth hormone and insulin-like growth factor-1 in tissue growth. This is referred to collectively as the GH/IGF-1 axis. We learned that this axis is controlled by negative feedback meaning that GH, after being released, circulates back to the hypothalamus and pituitary to effectively stop further GH release. We learned that circulating IGF-1 has the same inhibiting effect on GH release. We discussed very briefly the role of neurotransmitters in regulating GH release through growth hormone releasing hormone (GHRH) and somatostatin (SS). We even touched on the nitty gritty details of just how IGF-1 does its magic on muscle cells. I’m afraid I may have disappointed a few of you waiting for the “how to” section of this article. Never fear, in part II you will learn about the effects of these hormones as well as androgens, insulin and thyroid hormones when given, individually and combined, to previously healthy individuals. I will remind you that this article is not intended to encourage you put your health at risk, or to break the law by acquiring and using these substances illegally. As always, the goal ******* is not to condone the use of performance enhancing substances, but to educate by providing unbiased information about all aspects of high level sport performance and bodybuilding.

9:42am  |   URL: http://tmblr.co/ZqTeEu1MN68vm
  
Filed under: igf-1 GH HGH bodybuilding 
July 17, 2014
Masteron Information

Masteron (Drostanolone Propionate) is perhaps one of the more ‘exotic’ anabolic steroid that may be used by an athlete. Originally it was developed and used as an anti-estrogen (under the name Masteril) for the treatment of breast cancer. It was largely used in combination with the SERM (Selective Estrogen Receptor Modulator) Tamoxifen (aka Nolvadex) for the treatment of breast cancer, and did give a significant decrease in estrogen levels in women undergoing such treatment. It is not much used these days for such purposes, for varying reasons, however for many athletes including competitive bodybuilders in particular; Masteron remains a rather unsung favourite of AS medicines.

The fact that Masteron was being used as an anti-estrogen goes to suggest quite a lot about some properties Masteron possesses. Masteron is a derivative of DHT (dihydrotestosterone) and does not convert to estrogen through means of aromatisation. It is thought that the anti-estrogenic properties of Masteron may be in part to do with either an inhibition in some way of the aromatase enzyme or an interaction with estrogen itself in a way which blocks receptor binding of the estrogen. Either way, this would put Masteron as a useful tool for the anabolic steroid user who uses compounds that convert to estrogen (which most anabolic steroids users do, considering testosterone is the main basis of most cycles). By inhibiting the aromatase enzyme, Masteron would be in effect blocking the conversion of free testosterone to estrogen by the aromatisation pathway. This would not only serve to marginally increase the amounts of active free testosterone in circulation (thus giving a greater effect of the testosterone over a Masteron-free system), but it would also negate the side-effects that result from high levels of estrogen due to aromatisation. Such side effects include the development of gynecomastia and water retention/bloating. Conversely, if Masteron actually blocks the binding of estrogen to the estrogen receptor in some way, although aromatisation of testosterone may occur, its effects would be limited due to the inability of the estrogen to bind to the estrogen receptor. Thus through this mechanism, the effects of excess estrogen production through aromatisation would also be limited by use of Masteron.

Although Masteron contains such anti-estrogenic properties, it also (being a DHT derivative) has anabolic and androgenic properties. Although in theory and on paper it may be seen to be not a very strong androgen, in fact Masteron does give higher androgenic effects than one may expect. The use of Masteron, as it is an anabolic steroid, will shut down natural testosterone production and so despite having anti-estrogenic effects again, one must not think that Masteron could be used as an option in post cycle therapy as it will inhibit recovery.

There are two forms of Masteron that are generally available for use – Drostanolone Propionate and Drostanolone Enanthate. The propionate version is usually dosed at 50-150mg/ml and is the fast acting version of Masteron, needing to be injected every other day. The enanthate version of Masteron is dosed normally at around 200mg/ml and needs only to be injected twice per week as the ester attached to the drostanolone is longer thus giving a slower release of hormone.

Suggested Cycles/Uses
Due to the effects of Masteron on estrogen related side effects, Masteron is a very useful tool (especially in competitive bodybuilding) when cutting. As higher levels of estrogen result in water retention, Masteron inhibits water retention, and many users claim that their muscles feel very full and tight on Masteron, with it giving them amazing ‘muscle pumps’ in the gym. Use of Masteron (in combination with other appropriate meds) at low body fat levels results in the user seeing fine detail of the muscles being accentuated, such as striations and the fine details of the muscle. Masteron helps draw out the water from between the skin and the muscle giving this very cut look (at low body fat levels). Not many other anabolic steroid medicines can give such effects on muscle detail as those seen with Masteron.

Despite these effects of Masteron, it is a rather weak anabolic steroid in itself. One would hardly benefit at all from use of Masteron on its own, and furthermore use of Masteron alone may result in loss of libido due to shutdown of the body’s natural testosterone production. For these reasons, it is always recommended to stack Masteron with other steroids.

It is said by many that using Masteron is a waste when the user has a body fat percentage higher than 10-12%. I can understand the reasoning, and the user must understand that at higher body fat levels the detail to the muscle will not be seen in such a way as described; however I do not see it as a waste due to its anti-estrogenic properties. Such properties may allow one to not use other ancillaries on cycle that would have other undesirable side effects, and in addition Masteron may work in a synergistic fashion with other anabolic steroid medicines to amplify their effects (for example with testosterone as described above). Masteron would however not be recommended for beginner use as it is not needed at this starting out level.

Masteron can be pretty much incorporated into any cycle containing testosterone.

The dosages that should be used with Masteron are:

  • 350-500mg per week (propionate version, injected every other day)
  • 400-600mg per week (enanthate version, injected twice per week)

An example of an excellent cutting cycle for an advanced user would be:

(6-10 weeks)

  • 150mg Testosterone propionate every other day
  • 50mg Trenbolone acetate every day (or 100mg every other day)
  • 150mg Masteron (propionate) every other day
  • 50mg Winstrol every day, last 4 weeks of cycle only

Of course with such an intermediate/advanced cycle, the user could also incorporate other medicines such as Clenbuterol, T3, growth hormone, IGF, etc.

A more novice cutting cycle may consist of: (6-8 weeks)

  • 100mg Testosterone propionate every other day
  • 100mg Masteron (propionate) every other day

Possible Side Effects

As discussed, Masteron possesses anti-estrogenic properties which results in the elimination of many of the unwanted side effects that AS users may experience, such as gynecomastia, water retention and dangerous increases in blood pressure. Although Masteron is a weak steroid and on paper it has low androgenic properties, it has already been mentioned that in practice the androgenic properties appear to be slightly higher than in theory, and secondly Masteron is a DHT derivative.

Briefly however, the side effects that may occur with use of Masteron include hair loss (if prone to male pattern baldness), aggression and acne. If a user does experience acne with other androgens such as testosterone, then it is a real possibility that they may experience it with the use of Masteron. I know of people who experience only a few spots with the use of testosterone however when using Masteron they experience many more spots. On the other hand, there are users who seem to experience less spots on Masteron than they do on Trenbolone.

As with all anabolic steroids, it is impossible for anyone to say how an individual will definitely react in terms of side effects, etc with any medicine, as individuals will always differ in their responses to medicines, with differing severities as well. But the user must be aware that the potential is there, and thus take this into consideration when planning a cycle. There are medicines available to combat side effects, such as finasteride for baldness and accutane for acne, however these medicines also have their limitations and must be researched well before use.

Having said this, Masteron when initially produced pharmacologically, was seen by the FDA as a relatively safe medicine, even at high dosages. Dosages in excess of 150mg per day (that’s over 1000mg per week) were considered as safe limits by the FDA (bear in mind most other anabolic steroids used by athletes are used in levels that exceed FDA safe limits). This is good news to the user, however do not misinterpret this information as a reason to use excessive doses of Masteron as in reality anything above 600mg per week is not going to give any more benefit than 500-600mg per week would give, thus excessive use would be a waste of money and injections.

July 11, 2014
Clenbuterol

Clenbuterol (often referred to simply as ‘Clen’) is not a steroid, but a Beta 2 Sympathomitetic and central nervous system (CNS) stimulant. It is a specific agonist, stimulating the adrenergic beta 2 receptors. It is used in certain countries in a medical sense as a bronchodilator in the treatment of asthma, though not in the UK and USA, mainly due to its long half life.

Athletes and bodybuilders use the drug due to its thermogenic and anti-catabolic effects. This is down to its ability to slightly increase the body’s core temperature, thereby raising calorie (energy) expenditure. It is thought that a 1°F increase yields around a 5% increase in maintenance calories burned. Studies on livestock suggest that clenbuterol also has anabolic properties. However, this seems not to be the case in humans, thought to be due to the fact that humans lack the abundance of beta 3 receptors which increase insulin production and sensitivity.

Clenbuterol is dosed in micrograms (mcg/µg), most commonly in tablet form, though there are other forms of administration such as liquids, nasal sprays and injectables. Note: Although dosages are in microgram amounts, many manufacturers will list the active ingredient as milligrams (mg), so a tablet of 20mcg will be labelled as 0.02mg.

Side effects are dose dependant, though most users will find that most tend to subside with persistent use. Caution is advised when employing the use of Clenbuterol in conjunction with other adrenoceptor agonists as side effects are likely to be cumulative. It is for this reason that it is generally not recommended to use ephedrine/ephedra (or ma huang) or the ECA stack (ephedrine-caffeine-aspirin) whilst using clen.

Common side effects of clenbuterol include:

  • Headaches
  • Muscular tremors (especially hand shakes)
  • Muscular cramps
  • Nervousness
  • Insomnia
  • Sweating
  • Increased appetite
  • Nausea
  • Palpitations
  • Hypertension (high blood pressure) 
  • Possible cardiac hypertrophy as clen also targets cardiac and smooth muscle fibres 
  • Heart muscle necrosis has been demonstrated in animal studies

In view of the above side effects, it is obvious to assume that anyone with cardiac issues and/or hypertension should not use a stimulant such as Clenbuterol and caution must be observed by those already using similar compounds in the treatment of existing medical conditions. In addition, there is very little conclusive knowledge of the cardiac effects of supra-physiological dosages in humans.

Commonly used doses
It is well known that Clenbuterol use results in rapid down-regulation of beta 2 receptors. This is due to the powerful stimulatory effect of the drug. It is therefore pointless to use clen for long periods without a break. Some believe that a two day on, two day off dosing schedule will allow adequate potential for receptor up-regulation. However, I doubt this to be the case due to the relatively long half life of clen, resulting in continued stimulation even throughout the ‘off’ days. A much better regime would be a two week on, two week off cycle. Maximum plasma levels are reached around 2-3 hours after oral administration, and terminal half life at 34 hours.

A tapering up of dosages is recommended in an attempt to limit harsh side effects. Most commonly, a user will start by taking one 20mcg tablet on day 1, followed by an increase of one tablet on subsequent days. Subject to personal tolerance levels, a dosage of 140mcg (seven tabs) will be used by day 7, and this level should be maintained for the entire second week. It would be fruitless to exceed seven or eight tablets daily due to receptor over-saturation. There is no requirement to taper down.

For the next ‘cycle’ of clen (i.e. weeks 5 & 6), there is no requirement to taper up from one tablet as your tolerance level should now be known. As an example, if the user finished the first cycle of clen on 7 tabs, they could recommence at a slightly lower dose of 4 or 5, and taper up again from this level. Again though, the user should again limit their intake to 7 or 8 tabs daily.

Female dosages tend to be slightly lower than those of male users, with an upper limit of 80-120mcg (4-6 tabs).

Aside from its fat burning properties, Clen is often used as an anti-catabolic to maintain muscular gains following a steroid cycle. A dosage of 40mcg daily would be suited to this situation.

There is no particular requirement to split the dosage throughout the day due to the long half life. Most will take the full daily dose in the morning, though some prefer to take their dose just before bed in an attempt to avoid most of the side effects as they sleep.

Some user accounts suggest that splitting the dose may lessen side effects slightly. It is a trial and error process in essence, to ascertain which method suits you personally.

Muscular cramping
Cramping whilst using Clenbuterol is a fairly common side effect. This is most probably due to depletion of the amino acid taurine in the liver together with deficits in the electrolytes sodium and potassium, as well as inadequate hydration. Taurine helps stabilize cell membranes and prevent nerves from becoming over-excited. Some studies show that giving taurine supplements relieves painful muscle cramps. Japanese researchers found that the longer rats exercised, the more taurine they lost from their muscles.

Symptoms of cramping may be alleviated by:

  • Eating fruit particularly bananas
  • Ensuring adequate hydration
  • Taurine supplementation - 3-5g daily
  • Potassium supplementation - 200-400mg daily taken before bed on an empty stomach

However, bodybuilders are interested in the drug as it has been shown to inhibit the down regulation of the beta receptors, including the beta 2s that clen stimulates. As long as you are taking ketotifen, it will continue to clean these receptors, never allowing them to downregulate, even while on a heavy clen cycle. That means you can continue to take Сlen indefinitely without having to cycle off to regenerate the receptors. A dose of 2-3mg daily can upregulate even severely shut down receptors within a week.

It also means that you don’t need as much clen to get the same benefits. It seems you can take about 30-40% less clen and it be equally effective.

No studies have been done to find the most effective dose though most users should find 3-4mg daily ideal, which can be split or taken in one sitting. Higher doses are likely to cause (sometimes severe) drowsiness and increase appetite.

July 4, 2014
The Strategic Use of Four Kinds of Testosterone – Cypionate, Enanthate, Propionate, Suspension

The principal practical difference between these is duration of action.There’s also some difference in the amount of actual testosterone contained per milligram of drug. In order of highest testosterone concentration to least-high but still high, the order is suspension, propionate, enanthate, and cypionate.

In practice however, I suggest forgetting about that! Rarely does anyone account for this in deciding their testosterone dosage. It’s a point that may be glossed past with no problem.The above is also the order of duration of action, from shortest to longest.

For practical purposes, Testosterone Cypionate and Testosterone Enanthate may be used fairly interchangeably. The half-life of Testosterone Enanthate is probably about 4-5 days, while that of Testosterone Cypionate is probably about a day longer. Accordingly, both of these clear the body relatively slowly at the end of a cycle, causing a relatively long period where levels are neither high enough to allow much if any further gains, yet not low enough to allow recovery.

Testosterone Propionate has a much shorter half-life of probably only about 2 days. As a result, clearance of Testosterone Propionate is quick at the end of a cycle. By half-life, I mean the time period in which levels of drug drop by 50%. For example, if a drug has a one day half-life, then after one day levels will have fallen to ½, after two days to ¼, after three days to ⅛, etc.

Testosterone suspension has a variable duration of action of at least several days and up to at least a week. The pattern in which levels drop, however, is different from those of drugs having a half-life. Instead, particles of drug slowly dissolve, and the particles slowly shrink. Release slows somewhat as the particles shrink and their surface area decreases. Any given particle will at some point disappear entirely. When nearly all have entirely dissolved, the duration of action of the suspension has ended.
Because of how this works, duration is dependent on particle size of the suspension. This is variable between products. Broadly speaking though, products which are milkier, which take longer to fall out of solution, and which go completely easily through the finest needle will have shorter duration of action than coarser products.

A good suspension of testosterone can be used similarly to Testosterone Propionate.

I’d recommend saving the Testosterone Propionate and Testosterone suspension for use at the end of the cycle, to enable faster transition from high levels allowing gains to low levels allowing recovery. There’s no value in spending an extended time after the last injection with levels still too high to allow recovery, yet not high enough to allow further gains. Actually, it’s not just that there’s no value, but a negative value: it impedes recovery.

Strategic use of propionate esters and suspension at the end of a cycle aids rapid recovery.

June 26, 2014
Don’t Make These Fat Loss Mistakes When Going Low-Carb

Cutting your carbohydrate intake in favor of a high-protein diet is the simplest way to get lean fast. However, people often make mistakes when going low-carb, especially if they are training hard in an effort to accelerate the fat loss process.

With these five simple tips, you can make going low-carb a lot easier and get better fat loss results.

Mistake #1: You Are Not Increasing Protein Enough Low-carb diets are naturally higher protein diets, but one problem a lot of trainees have is not boosting protein intake sufficiently. If you are training hard and going low-carb for the first time, you need to increase protein by at least 50 percent. If you’ve been limiting carbs for a while, troubleshoot the makeup of your diet by ensuring carbs are less than 50 grams, strictly from green vegetable sources, and increase your protein by 20 to 50 percent.

Mistake #2: You Are Not Getting Enough of The Right Fats Low-carb diets should also naturally be higher fat diets, but the fat MUST come from healthy sources—omega-3s, medium chain triglycerides (MCTs like coconut oil), and monounsaturated fats (olive oil and avocado, for example). The omega-3s are considered essential fatty acids (EFAs) and they have the excellent effect of encouraging fat burning. In addition, consuming MCTs can substitute for glycogen in the body when you are training at high-intensity.

As you know if you’ve ever trained in a glycogen depleted state, it can be particularly painful and some people experience a drop in performance. Training this way is a necessity if you want to lose fat fast, but simply, it sucks. One way to help avoid this is to supplement with MCTs like coconut oil prior to your workout because the body will use it for energy. Try cooking your pre-workout meal in coconut oil (or just supplement with 2 tablespoons) 60 minutes before your workout. Mistake #3: You Are Low In Sodium & Potassium Instead you want to ensure you are taking in sodium either in diet or in supplement form. One study found that supplementing daily with 3 to 5 grams of sodium and 2 to 3 grams of potassium allowed subjects who were exercising on a low-carb diet to maintain circulation and avoid losing muscle mass. Take electrolytes to get both sodium and potassium together. Cooking with meat broths and using Celtic or Himalayan salt on your food can also help.

Mistake #4: You Are Deficient In Magnesium Unless you supplement with magnesium, you probably have horribly low magnesium that is stunting fat loss. When you cut carbs and train hard, magnesium can be depleted due to its role in insulin metabolism. Avoid this by supplementing with a high-quality magnesium blend such as magnesium glycinate and magnesium taurate, but avoid magnesium oxide as your sole source because of its poor quality.

Mistake” #5: You Are Not Taking Advantage of Caffeine This one isn’t a “mistake” since using caffeine is a personal choice and people respond differently to it. However, supplementing with caffeine pre-workout when on a low-carb diet can give you a major boost and accelerate fat loss.

A recent study found that when trained cyclists took 3 mg/kg/body weight and performed eight 5-minute “sprints” at maximal capacity in a glycogen depleted state they performed significantly better than a placebo group. Caffeine enhanced power output during the workout and is suggested as a means of enhancing performance when you have low energy stores and want to lose fat.

Larger caffeine doses may have even greater performance-enhancing effects—8 mg/kg/body weight has proved ideal in non-glycogen depleted athletes.

June 20, 2014
How To Cycle Sustanon 250 (Testosterone)?

Sustanon injection contains testosterone esters. These are derivatives of the naturally occurring male hormone testosterone. They are converted in the body to testosterone. The steroid of choice was Sustanon (Sustanon 250)… it was a household name to bodybuilders. In short, Sustanon is a blend of four testosterones in one. Some of the esters are fast acting, while others slow acting.

Sustanon injection is called a depot injection. It is injected slowly into the muscle where it forms a reservoir of medicine. The testosterone is gradually released all the time from the reservoir into the bloodstream.The natural production of testosterone is controlled by another set of hormones called gonadotrophins, which are released from the pituitary gland in the brain. Two, less frequent injections were not ideal.

Three, in the end testosterone is testosterone. It was originally believed that a blend of these testosterone esters would yield bigger gains, then that of a single ester, such as, enanthate or cypionate. Add in the cost of the single esters, compared to the brand name Sustanon, and steroid users were making other choices. Even with the advancements made over the last couple decades, beginners and even advanced users still seek out a Sustanon cycle. The three steroids used are Sustanon, Deca Durabolin (Nandrolone decanoate), and Dianabol (Methandrostenolone). The addition of Dianabol gives the individual immediate results, putting on several pounds in the first week alone, however, it is mostly water weight.

During adult life, testosterone is essential for the production of sperm, the maintenance of sex drive, erectile potency, and the functioning of the prostate gland and other reproductive structures.Low levels of testosterone can cause decreased sex drive, impotence, infertility due to decreased sperm production, decreased mental and physical activity, fatigue and weakening of bones.Testosterone replacement allows natural testosterone levels to return to normal, thus relieving the symptoms of the deficiency.

Recommended Sustanon dosages have crept up over the last ten years. Originally, it was suggested to take 250mgs per week of Sustanon. Users would report 15-25lbs of weight gain over a short 8 week period. But this was not enough, and as mentioned in the Winstorl cycle, people always believe ‘more is better’, and now the most common beginner dose is 500mgs per week.Injecting Sustanon every other day is the ideal method, but it creates a problem. Sustanon, 95% of the time will come in 250mg dosages. If a user takes 250mgs of Sustanon every second day, that’s 875mgs of testosterone a week, which is a high dosage for beginners and intermediate steroid users.

Even with the advancements made over the last couple decades, beginners and even advanced users still seek out a Sustanon cycle. Stories of the ‘gains’ from Sustanon have been passed down over the years, making it a legend in the steroid black market.Not only the most popular Sustanon cycle, but one of the most popular cycle all time, is the Sustanon mass stack. It’s a mass building cycle aimed towards intermediate users, but some first time users have also jumped right into it.

As with most steroids, there are chances of side effects. Possible side effects include acne, gynecomastia, testicular shrinkage, and more. It is suggested to have a product like Nolvadex(Tamoxifen citrate) on hand, in case estrogen becomes an issue and gynecomastia develops. The lower the dosage, the individual greatly decreases the chance of any side effects.

June 6, 2014
Mega dosing, stacking, cycle duration and tapering steroid cycles.

With the wide variety of anabolic steroids available, planning the most appropriate cycle may seem like a difficult task to the steroid novice. Even if we have settled on a particular drug or drug combination, it is still easy to question whether or not we are using them in the most effective manner. This is one of those topics which can get more confusing with research, as you will find the popular literature filled with various stacking, cycling, tapering and receptor response theories. I have actually developed the opinion that athletes usually place too much importance on cycle construction. Experimenting with fancy dosing patterns, rotation schedules and [especially] tapering routines, hoping they will bring about enhanced results, is in my opinion a very unreliable practice. In this section I will therefore be ignoring the more lavish intake regimens, and focus on the more fundamental aspects to using these drugs. This is obvious when you look at the sample cycles included, which you will notice display little fluctuation in drug dosages from start to finish. They are not fashioned as such due to laziness, but simply because my personal experience has led me to a place where picking a dosage and sticking with it [unless there is an obvious need to adjust] seems to make the most sense. Of course it is ultimately up to the individual to find out what works best for him or her, as nobody can rightly claim that there is one “correct” way for everyone to use steroids. Here are a few things to think about when deciding on the right cycle for your needs.

Stacking

It is an extremely common practice for an athlete to take more than one individual steroid during a cycle. By taking a combination of steroids, the user is of course seeking to enhance the amoun/quality of muscle mass gained from drug therapy. While I am sure it is no surprise that stacking is generally an effective practice, you should probably give some thought to expected goals and side effects before simply combining steroids. If you are looking to gain considerable mass for example, the use of two strong androgens like testosterone and Anadrol 50 would be one of the more potent cycles to attempt. But this combination would also lead to very harsh side effects, and may be too uncomfortable far some individuals. In this case it may be a good suggestion to combine a milder anabolic with a base androgen instead. A stack such as Deca-Durabolin and Dianabol would still produce very formidable muscle mass gains, but would provide to user much less water/fat retention, gynecomastia, hair loss/growth and acne than the former.

On the other hand, “anabolics” are typically the favored class of steroids for cutting/dieting phases of training. This is because most have little or no tendency for estrogen conversion, which as you know makes them less apt to induce fat and water accumulation. It is important to remember however that these steroids can still suppress endogenous testosterone production during a cycle. Since the administered drugs may not provide the body enough androgen content to compensate for this loss, this type of cycle may sometimes interfere with aggression and libido (Deca Durabolin is a common offender). In such a state the user might become depressed and unmotivated [see: side effects, depression], seriously reducing the quality [results and comfort] of the cycle. It is therefore usually a good idea to include some type of androgen during this type of cycle, especially if you have experienced such problems before. The preference would be a non-aromatizing androgenic compound like Proviron, Halotestin or Trenbolone, which will not increase the likelihood for fat/water retention. In the absence of excess estrogen, the heightened androgen level brought about by these drugs can actually enhance the removal of body fat, and noticeably increase the look of hardness/density to the physique (provided the users body fat percentage is low enough to make this visible). Such compounds were unavailable, perhaps a weekly (low dosage) shot of testosterone would prove sufficient to ward off any problems.

Finally, is also good to remember that it is not absolutely necessary to take more than one steroid at a time. The term you hear most often is synergy, which implies that two [or more] steroids used together will often compliment (and amplify) each other, providing a greater muscle gain than if they had been used consecutively. Though not well understood, a number of studies do suggest that different modes of action might exist for steroids outside of the androgen receptor [which would seem to support the notion that cooperative or synergistic effects can be seen with different drug arrangements]. Athletes also seem to know that certain drug combinations work extremely well together [Deca Durabolin & Dianabol, Testosterone and Anadrol 50, Trenbolone and Winstrol etc.], which is a testament to the notion of drug synergy. But this should not be confused with the idea that you cannot make gains on one drug alone. An athlete new to the world of steroids could make exceptional gains on a cycle of testosterone, Anadrol 50 or Dianabol for example, without ever needing to add a second drug. Heavily increased dosages and multidrug stacks are likewise most prominent among those who are already very familiar with steroid use, and find they are necessary in order to continue to gain or maintain muscle mass.

Dosing and Megadosing

There are many different opinions as to exactly what dosage an individual should use of any particular drug in order to elicit optimal results. Some seem to find they make exceptional gains on relatively low dosages of most steroids, while others insist they need to administer very large amounts of androgens for the proper level of bulk. While I would be no means claim to have the solution for everybody, I would say those most steroids seem to work their best in a particular range of dosage, and usually fall short of expectations as we go higher or lower. On the one hand we may find that going below what is considered to be a normal dosage for a specific drug will cause a very poor gain to be achieved, the hormone level perhaps not rising enough above normal to stimulate a considerable response. For example, 200-800mg of Testosterone Enanthate per week is typically sufficient for a man to receive very formidable gains, while 50-100mg may not provide very noticeable results at all [of course this is all common sense]. On the other extreme, athletes generally find that unusually large doses [lets say 1000-2000mg per week] will provide a relatively low quality increase over that of the normal dosage range. Yes, the amount of muscle mass may be considerably more than expected with a typical dose, but this will probably not be proportionate with the gain of new body fat and water weight. The user will typically be stuck with a much more noticeable level of side effects, while receiving a poor return [as in solid muscle mass] on his money. 

Cycle Duration

There are also many arguments as to how long one should stay on a steroid cycle before taking a break. Opinions range from those of cautious individuals, who are often vehement about short cycles and long off-periods, to the seriously hard-core user who suggests year round use for optimal results. Since it is really up to the individual to choose the cycle that is best for him or her, I can only provide some very basic advice. For starters, it is very important to watch your intake duration when on stronger or more toxic substances. This includes all c17 alpha alkylated orals, or high-dose cycles of easily aromatized steroids. These compounds place the most stress on your organs, and likewise should be utilized for only limited intervals [preferably less than 8 weeks]. Afterwards a break of at least as much time [preferably more] should be taken to give the body ample time to rest/recover. For those who refuse to follow such advice, blood work and regular health checkups should be an absolute necessity.

When taking milder anabolics like Deca-Durabolin, Primobolan or Equipoise, one might opt to take the drugs for a longer duration. This is due to the fact that these compounds do not act in an extremely dramatic manner, and instead promote a slow but consistent buildup of muscle tissue. With this understanding it is not unusual for an athlete to find a cycle of three, even four or more months to be the most appropriate. If used for only a short duration, the individual might find the overall gains to be uninspiring. Year round, on-all-the-time steroid use should be avoided if at all possible, as one should respect the natural hormonal balance your body strives for. The body really should be given time to regain a natural hormonal balance every so often, to ensure that there is little possibility of future problems. Although many believe the effects of these drugs to be 100% fully reversible, it is not impossible to see problems with virility, libido etc. after the body had been overloaded with hormones for many years. The health risks associated with elevated cholesterol levels, high blood pressure or liver toxicity are of course also important reasons the athlete should limit the duration of steroid intake.

Tapering

One of the most fundamental beliefs among steroid users is that tapering, or the practice of slowly reducing their drug dosage when discontinuing a cycle, is an absolute necessity when wishing to preserve your newly gained muscle mass. It is rare to find an athlete who does not religiously dedicate [at least] three or four weeks to a tapering schedule after every serious cycle. The obvious belief is that the body will notice the lowering androgen level, and compensate by resuming the manufacture of testosterone. Unfortunately you will see that this theory is in fact, extremely flawed. This is because in order for the production of testosterone to be fully restored, the body will really need to recognize an androgen deficit, not just a drop in steroid dosage. Since for example even one Dianabol tablets could provide the equivalent of a days androgen supply for the average male, tapering from five, to four, to three etc. will accomplish relatively nothing. In the three or four weeks the athlete will spend doing this, his body is still reading “androgen overload”, and is not attempting to restore the output of testosterone. This will of course hold true for all anabolic steroids, not just the strong androgens. Anecdotal evidence suggests that even tapering with mild anabolics such as Primobolan or Anavar [normally thought of as mild in terms of testosterone suppression] is enough to prevent or delay a hormonal rebound.

So if tapering is useless what should the athlete do in order to properly discontinue a steroid cycle? Of course the obvious answer is to pay much closer attention to ancillary drug use than tapering. The proper application of testosterone stimulating compounds like HCG, Clomid, Nolvadex are the most critical, as these can greatly aid in the balancing of body hormones. [The popular methods for using all the above medications are laid out under their individual profiles.] In the few cycles I have illustrated in this section you will notice that I have not even bothered to lower the drug dosages before the ancillary drugs are added. Simply put, there is no need to. In my opinion going “cold turkey” is just the most logical option.

Sample Steroid Stacks

Sample steroid stacks are provided to demonstrate common and/or effective drug combinations in use by bodybuilders. For most of these cycles, the dosages used are in the moderate range. They are intended to represent a balance of peak effectiveness with tolerable side effects, and are also designed so that they can be assembled with very basic and common black market items. For most novice steroid users, stacks like these provide more than a sufficient level of steroid for very dramatic results. Some even find that they can make substantial progress on much less. These represent only common guidelines toward typical use, and by no means are indented to be the perfect cycles for everybody. You will also notice that I have not provided cycles geared towards women. This is quite simply because I think women should be extremely cautious with these drugs. Those absolutely determined to use them should certainly avoiding multiple drug combinations, especially as a novice to these agents.

May 30, 2014
How to Protect the Liver During Anabolic Steroid Use

First, liver harm from anabolic steroids comes principally or entirely from alkylated anabolic steroids. Where the steroids are non-alkylated and estradiol levels remain normal, there’s almost never harm to the liver from steroid use. Example non-alkylated steroids are testosterone, Masteron, Trenbolone, Boldenone (Equipoise), Nandrolone (Deca Durabolin), and Primobolan. Keeping liver safety in mind, an effective cycle should have one or more of these steroids as the base, or even as the entirety of the cycle.

About 350-700 mg/week of a steroid stack, though, may be an alkylated compound. The most common alkylated steroids are Dianabol, Anadrol, Oxandrolone (Anavar), and Winstrol.

Alkylated steroid use is preferably limited to only six weeks at a time, though of course many who go longer don’t suffer lasting harm. However, sustained use of oral anabolic steroids absolutely can cause undetected formation of scar tissue in the liver. This effect can be cumulative, as the scar tissue does not heal. And thoroughly excellent gains can be achieved without “pushing” the 6-week rule.

If cycle length is greater than 6 weeks, then appropriate amounts of testosterone can substitute for the orals. I replace Anadrol or Winstrol with testosterone on a milligram for milligram basis. I replace Dianabol on a three-to-two basis, or in other words, 50 mg/day Dianabol is replaced by about 75 mg/day of testosterone.

Oxandrolone, on the other hand, is replaced with Masteron on a three-to-two basis, or trenbolone on a two-to-three basis. Each period of alkylated steroid use should be followed by about twice as much time not using alkylated steroids, or longer. Estradiol preferably will be kept in the normal range, or not much above it, as elevated estradiol is slightly liver toxic. In and of itself estradiol toxicity is not greatly important, but in combination with alkylated steroid use, it adds to the toxicity.

Obviously hepatotoxic drugs and excessive alcohol use should be avoided, as should heavy use of NSAID’s, aspirin, or acetaminophen. Cautious use is fine.

May 23, 2014
Testosterone Myths

Low testosterone has emerged as an umbrella cause for numerous male health problems. Bombarded by advertisements suggesting insufficient testosterone could be causing everything from depression to low sex drive, men are increasingly seeking information on the male sex hormone. However, not all of the available information is accurate.

Even in the nutrition and healthcare industry, trending topics generate just as many myths as usable truths. And because many people turn to testosterone for a boost in strength and athleticism, men must also sift through marketing claims when assessing testosterone. Unfortunately, these irrational beliefs and fears have kept men from trying hormone replacement therapy and testosterone-boosting supplements to improve flagging testosterone levels.

To dispel these common misconceptions about testosterone, here are five myths and the truths behind this hormone. Hopefully this dispels any fears you have about seeking treatment, or even trying a testosterone supplement to boost athletic performance.

1. Only Older Men Struggle with Low Testosterone

While it’s true that older men disproportionately struggle with low testosterone thanks to andropause, low testosterone levels can affect men at any age. Even teenagers may suffer from low testosterone: known as hypogonadism.

During youth, testosterone is produced at a relatively steady rate. It helps trigger the onset of puberty and maintains bones, muscles and sex drive. However, after age 30, most men start to experience a gradual decline in testosterone. Because testosterone declines progressively, most men don’t notice symptoms of low testosterone until their late 50s or early 60s. However, if the decline is too steep, testosterone can dip below recommended levels at a young age.

This means that, however remote the chances, every man is potentially at risk for low testosterone. Fortunately, medication and nutritional supplements are available to correct the imbalance. Not so fortunately, additional testosterone myths prevent some men from trying them.

2. Testosterone is Illegal and Dangerous Because it’s a Steroid

Testosterone is technically a steroid, which leads many men to erroneously assume using testosterone is illegal and even dangerous. However, neither assumption is true. Testosterone is not illegal in the US. In fact, it’s entirely possible to obtain legal prescription medications or injections in the US. There are also hundreds of supplement companies vying for your attention with advertisements for supplements that supposedly trigger greater testosterone production—all within the bounds of the law.

However, many sports organizations do have rules about substances like testosterone that influence athletic performance. Violating such organizational rules may have severe consequences, especially for professional athletes.

The second claim – thattestosterone supplementation is dangerous – is also untrue. Steroids are simply molecules with four rings of carbon. Following that definition, even cholesterol is a steroid. While testosterone may be classed as an anabolic steroid because it builds muscle, it is relatively safe, even in high concentrations. While abuse of any anabolic steroid is potentially dangerous, testosterone is relatively safe and doesn’t cause life-threatening side effects when used appropriately.

3. Supplementing with Testosterone Causes Aggression

Even men who know testosterone supplementation isn’t life-threatening, are kept away by fear of lower-risk side effects. Perhaps the most common side effect-related misconception is supplementing with testosterone increases aggression, causing uncontrollable and even violent behavior.

However, there is absolutely no reliable evidence supporting these claims. In fact, a 2000 study conducted by Harvard researcher Harrison Pope finds no difference in mood between men supplementing with testosterone and men in a control group. During the study, 50 men were given high testosterone doses, higher than was needed for hormone therapy. However, only two men developed measurable aggression as a result. What’s more, the opposite appears to be true: men with low testosterone are more likely to be irritable and short-tempered. This condition even has a name: irritable male syndrome.

4. Testosterone Use Leads to Baldness

Another commonly-cited testosterone side effect is male pattern baldness. Because baldness treatments typically block conversion of testosterone to dihydrotestosterone (DHT), many men assumed testosterone is the root cause of a receding hairline. However, this is not the case. In fact, men with male pattern baldness generally have the same testosterone levels as men with a full head of hair.The confusion?

Men who are already pre-destined to go bald typically do so when testosterone concentrations are especially low or high. To prevent these wild fluctuations, baldness medication limits testosterone levels, which affects the amount of testosterone that converts to DHT. Because the scalp needs very small amounts of DHT to carry out tasks pre-programmed in the genes (such as losing hair), an excess of testosterone and DHT can trigger earlier and greater baldness. Thus, limiting DHT becomes helpful in preventing baldness.

If your family history suggests you’ll go bald, high testosterone levels may increase the likelihood of the unhappy event. Fortunately, many testosterone boosters contain ingredients specifically inhibiting DHT, keeping you safe from this side effect.

5. Testosterone Increases Prostate Cancer Risk

Perhaps the most insidious testosterone myth is increasing testosterone levels through supplementation or injection increases your risk of developing prostate cancer.

This myth originates from studies in the 1940s in which men with metastatic prostate cancer exhibited improvements when they were castrated. Scientists pointed to testosterone as the likely cause of these benefits. However, subsequent research reveals men with existing cancer are the only ones affected by high testosterone levels. Furthermore, more recent studies have failed to establish testosterone suppression provides a clear decrease in prostate cancer risk.
This suggests you should see a doctor before beginning testosterone supplementation, as testosterone exacerbates cancer and triggers metastasis. However, if you don’t have cancer, increasing testosterone will have no effect on your prostate or your likelihood of developing cancer.

Using Testosterone in the Correct Way

If you suffer from low testosterone levels, consult your doctor about treatment methods. He or she will be able to direct you to the best possible treatment for your condition. This way, you won’t have to worry about user error or any other variable that may cause side effects.
As for testosterone supplementation, most test boosters use accurate dosing levels. If you follow manufacturer instructions, you shouldn’t have to focus on anything other than the benefits.

If you have questions or concerns, consult your doctor before beginning a testosterone supplement.

May 16, 2014
Trenbolone Acetate by Jintani Labs

Trenbolone Acetate is often considered the ideal muscle-building compound that can be utilized by strength athletes and bodybuilders. Its appeal is that it is strong androgen but has no estrogenic activity. This combination, along with the fat-burning properties of the drug that will be detailed later, makes it a potent compound that offers several advantages. These advantages however are tempered by some serious consequences if used improperly.

Trenbolone Acetate is a 19-nor steroid and is derived from the compound nandrolone. The difference between it and nandrolone are the c9 and c11 double bonds. The c9-10 double bond is the reason that trenbolone has no estrogenic activity. This bond is necessary for the aromatization of the A ring to be possible and by occupying this bond, no aromatization can occur

Trenbolone Acetate can affect muscle growth in several different ways, making it one of the best compounds for both maintaining and adding quality muscle mass. First, Trenbolone Acetate can greatly increases the level of IGF-1 within muscle tissue. It also causes muscle satellite cells, those responsible for repairing damaged muscle fibers, to be more sensitive to IGF-1 and other growth factors. The amount of DNA per muscle cell may also be significantly increased by using Trenbolone Acetate.

Trenbolone Acetate has an extremely strong binding affinity for the androgen receptor as well, even surpassing that of testosterone. This of course supports the assertion that Trenbolone Acetate is extremely anabolic as by binding to the androgen receptor a compound is able to activate the anabolic mechanisms that are dependent upon the androgen receptor, one of the many ways that anabolic steroids aid muscle growth. Like most other anabolic steroids, Trenbolone Acetate also increases nitrogen retention in muscle tissue. However a rather unique characteristic of the drug is its anti-catabolic abilities. Trenbolone Acetate binds with the receptors that interact with glucocorticoid hormones, these being catabolic hormones. By being able to inhibit cortisol and some other catabolic hormones in the body trenbolone is ideal for those users that are attempting to reduce body fat as the compound will help to minimize muscle wasting when running a calorie deficit.

Due to the fact that Trenbolone Acetate is manufactured for the sole purpose of use in animals, there are a few studies that address its potential effects in humans. Therefore it should be noted that the effects and safety of Trenbolone Acetate for human use are being extrapolated from animal studies. This is not to say that nothing can be learned from animal-based research, but the findings of these studies are simply not one hundred percent transferable to use in humans.

Despite this caution, Trenbolone Acetate does have tremendous results with commercially raised livestock and these results have led countless strength athletes and bodybuilders to experiment with the compound. Most often it is the concept of “feed efficiency” that is cited when people expound the virtues of Trenbolone Acetate. Basically the concept refers to the ratio of feed that results in meat from the animal that can be sold commercially. Trenbolone Acetate has been shown in countless studies and real world use to add muscle to livestock without any changes in diet. This improved feed efficiency is a result of Trenbolone Acetate ability to have the body more efficiently process and use the feed given an animal, as well as utilizing the vitamins and minerals ingested at a greater rate. This is exactly what a user would hope for in a compound and anecdotally users of Trenbolone Acetate have reported that the compound does indeed deliver on its potential, providing the user with dramatic gains.

Like other steroids that are extremely androgenic, Trenbolone Acetate offers several advantages for a user. First, due to the androgenic nature of the drug a user can expect a large increase in their strength. This makes the compound extremely popular with strength athletes. However bodybuilders looking to reduce their body fat also find that Trenbolone Acetate can help them achieve their goals as well. This ability to help in the reduction of body fat stems from the drug’s affinity for binding to the androgen receptors. These androgen receptors are located in, among other places, fat cells. When these androgens bind to the androgen receptors they can affect these cells and increase fat-burning. When this is combined with the fact that Trenbolone Acetate has a cortisol reducing effect along with the ability to bind to the glucocorticoid receptor, it can be understood why this compound is so highly touted for dieting and the reduction of body fat.

As for the ester of Trenbolone Acetate, acetate is a relatively short-chain ester. It has an active life of two to three days. Ideally a user would use daily injections to keep blood levels of the compound fairly stable, however injections every other day will suffice. The Trenbolone Acetate ester provides a rapid and high concentration of the hormone which is beneficial to those seeking quick gains, and coupled with a rapid clearing time the acetate ester can be discontinued on the onset of adverse side effects without having to wait days or even weeks for it’s effects to diminish.

In terms of cycle length, due to the liver toxicity associated with trenbolone most inexperienced users will limit their use of the compound to about eight to ten weeks. However, like most compounds, more experienced users have stretched these limits to accommodate their goals. However if a user chooses to extend their use of the compound for lengthy periods of time it is imperative that kidney and liver values are monitored to ensure that no damage to the organs is being done.

Dosages for users are highly dependent on how they react individually to the compound. Many users anecdotally report that side effects are minimal if doses are kept at certain levels but can turn rather harsh if doses are increased even slightly. For this reason it is important that inexperienced users start with low doses of the compound to judge their reaction to it. 50mgs per day is often cited as the standard starting point for most. However doses even lower than this, such as 75mgs every other day, are used by some with good results.

May 8, 2014
Anabolic Steroids, Sex Drive and the role of Estrogen, DHT, and Progesterone

Your libido is, well, essential. That is an understatement. If you can’t feel like a man, no use looking like the best built one. Okay, some things are known about male sex drive, many things are not. We will focus on what we do know, and, what the majority of cases I’ve seen have taught me. We have already mentioned much of the effect of DHT on the sex drive in the DHT section, however, we can expand a bit and give you some more useful and practical information. With respect to anabolic steroids, the male sex drive is affected by the following.


1) The androgenicity of the drug(s) used.
2 ) The aromatizing qualities of the drug(s) used.
3) The progestagenic influence of the drug.
4) The total amount of drug(s) in the system at any give time.


1) First, the androgenicity of the drug. In general, anabolic steroids that are highly androgenic have an intense affect on the libido. Testosterone makes you horny. Unless you have been on a cycle forever with no break, the first few days and weeks of test use definitely increase sex drive. Dianabol is also a popular one for making juicers super horny. These drugs in almost all of the literature are known “androgenic drugs”. These are two no brainers. This is just the ground level illustration of anabolic steroids having a positive affect on sex drive.

Nandrolone, as we’ve mentioned has a lessening affect on the sex drive. This is variable from person to person as we’ve stated previously, but is largely related to dosage. The reasons why we have discussed in the DHT section. Whether or not you agree or whatever you’ve read that may be different is always informative. Hey, the more you read, the better off you’ll be. Just be careful to pick and choose the advice you follow wisely. Okay, anyway, we all know deca has a negative affect on your sex drive. The half-life is very close to Deca but exceeds it by a few days. The literature often says two weeks or more, but from experience, I’d say Deca five to six days. The shorter acting versions such an Nandrolone phenylpropionate will also have the same affect. Also, the onset of Nandrolone phenylpropionate will be faster which will probably cause you to notice a decreased sex drive earlier in your cycle. Remember that many side affects with anabolic steroids are duration dependent as well as dosage dependent and you may not always experience the effects listed in the information sources you read and study.

Trenbolone is interesting because much of what you read will end in two truths. Number one, it is androgenic (some literature actually says six times more androgenic thatn testosterone), and two, it is a progesterone derived drug. This sounds like a paradox. For functional purposes, tren is a hearty androgen that also has a chemical structure that is very similar to progesterone. Trenbolone is also non-aromatizing. The real world application is that tren can make you strong and grow like you are on test, without the water weight (there will be no estrogen), and without the increased sex drive caused by testosterone (because of tren’s anti-libido progestagenic affect).


2) Aromatizing drugs affect your natural testosterone production by interfering with the classic feed-back loop. Most know that hight estrogen levels affect your pituitary gland and shuts down your body’s natural production of testosterone. The pituitary gland is a master regulator of hormonal levels. Actually, it is controlled by the true master gland, the hypothalamus…but this can get confusing and will take us off topic. For now, just know that the pituitary senses high estrogen or progesterone, and shuts off a hormone called leutinizing hormone or LH. LH travels from the pituitary to the testes, finds specific cells called Leydig cells, and tells the Leydig cells to kick out some test. If you interefere with this message, you interfere with natural testosterone production. This is called the hypo-thalamic-pituitary-testicular-axis. All this means is a loop that senses estrogen or progesterone levels for the purpose of regulating testosterone. This is also the very loop that makes anti-estrogenic drugs effective at increasing your testosterone levels post cycle.

Once your system is clean from anabolics (days to weeks depending on the dosage and drugs used), use of anti-estrogens work to block the estrogen from the pituitary, thereby telling the pituitary, “hey, we don’t have enough testosterone round these parts, fire some up there Billy Bob”. The pituitary then sends/ allows LH to be produced once again where it then travels to the Leydig cells of the testes, and stimulates the machinery to turn back on. You will know when this happens because this is when you can first tell that your balls are getting bigger again, your energy level comes back up, you start to feel good again since being off, etc. Common drugs that aromatize include the nandrolones, dianabol and all the testosterone esters.

The rest of the anabolic steroids are constantly disagreed upon amongst gurus, and their outcomes are not definitive enough to mention in detail, whether you are considering the likelihood of chemical structures, or empirical real world effects. After all, Deca Durabolin, Testosterone and Diamnabol are the drugs most used that will be the major culprits with regards to aromatization. I know, you all have probably known someone who has gotten some nasty estrogenic type side effects from some other drug besides deca, test or d-bol. Those side effects come from other root causes…However you look at it, estrogenic affects from anabolic steroids serve to decrease sex drive by shutting off your natural supply.

Only if the drugs are androgenic enough and affect the sexual areas of your brain in just the right way will the drug cancel its own affects and increase sex_drive. Your individual biochemistry comes into play with many of the sexual highs and lows of anabolic steroid usage, it takes individual experience to know what you need and when. But the information found here will hopefully take much of the guesswork out of your experiences.


3) Progestagenic Affects of drugs are often over-looked. This is because most individuals do not know how potent progesterone really is in the body. All you ever really here is the bad stuff about estrogen. Well, progesterone my friends can be pretty nasty. Remember what we’ve said about sex offenders and progesterone. the govenment itself uses progesterone treatment to kill the sex drive of male sex offenders in order to help control their cravings. If it works on a freak, it will definitely work on a normal person. Don’t forget, progesterone kills sex drive in the male.

As an important side note…I’ve tried hard to not believe everything I’ve ever read or studied unless there is:

1. Good and reasonable scientific rationale (not necessarily proof though, legitimate scientific tests always lag way behind empirical evidence)

2.Empirical Evidence

By good scientific rationale, I am referring to a logical reason(s) for a given occurrence to take place. Fore example, with progesterone, it is known that the male breast contains receptors for progesterone. This is known by testing of subjects who have clinical gynocomastia from causes other than anabolic steroids. Also, progesterone is meant to sensitize the body’s estrogen receptors to estrogen. Everyone knows that anadrol (a potent progestagenic anabolic steroid) can play a key role in the development of gyno. However we now know as fact that drol cannot aromatize due to its chemical structure. It is impervious to the enzyme aromatase which is the only enzyme that can do this job. And yet, drol can still cause gyno, right? Well, not exactly.

The two reasons why drol can influence gyno have already been said, but have not been grouped together. The reasons are:


1.Anadrol has a potent progestagenic affect.
2.Anadrol may sensitize estrogen receptors to estrogen. With respect to drug potency and effectiveness you can either increase the amount of drug available, or increase the sensitivity of the receptor(s). In the case of anadrol, the drug both acts sufficiently to affect progesterone receptors, and acts to sensitize estrogen to its own estrogen receptors.

Trenbolone also has progestagenic affects. Tren, as we’ve previously said, possesses strong androgenic properties. Tren is not known in the anabolic steroid community to cause gyno. However, it would be interesting to observe many cycles of anabolic steroids which include a heavily aromatizing steroid with trenbolone. No doubt many athletes have combined tren and testosterone with miraculous results. It would be interesting to note amongst these individuals if they have ever developed gyno when combining the drugs, but not when taking them alone. Remember, progesterone sensitizes the body to estrogen, so whatever estrogen is available will be more likely to act out and cause the negative effects we know estrogen is responsible for.

The moral of the story is to be cautious and knowledgeable about the drugs you are combining. Actually, that should be true whether you are 21 and raving at a night club on e, or a responsible individual, through with your party stage, and maximizing your safe use of anabolic steroids. Drug synergy can be an amazingly useful tool when used for maximal gain, but can be very unfortunate and even dangerous if multiple negative properties of drugs are allowed to gather inside the body.

May 2, 2014
Growth Hormone and Memory: Building Muscle as well as Improving Brain Function

Growth hormone replacement unequivocally benefits growth, body composition, cardiovascular risk factors and quality of life. Less is known about the effects of Growth hormone on learning and memory. The recent paper on ‘early onset – Growth hormone deficiency results in spatial memory impairment in mid life – and is prevented by Growth hormone supplementation’ by Nieves-Martinez importantly adds to this literature. Other data suggest that Growth hormone beneficially affects cognitive function in rats. In man, treatment of Growth hormone deficiency has been associated with improvements in measures of memory and attention. There are also differences in verbal memory of patients with childhood onset Growth hormone deficiency. Further questions remain, and the beneficial effects or otherwise of treating Growth hormone deficiency in different age groups remain to be better defined. Certainly for reasons of maturation of neural connections and their development to young adulthood contemporaneous with rises in Growth hormone and IGF1 make these important areas for further study in man. Lastly because of what we already know in terms of cognitive effects of Growth hormone deficiency, it is important to replace Growth hormone when studying other potential causes of adverse effects on cognition, for example, with radiotherapy.

Much has been written about the effects of growth hormone replacement therapy in Growth hormone-deficient human subjects on growth, body composition, cardiovascular risk factors, bone and muscle development and quality of life. When properly administered and monitored, the effects of Growth hormone on all of these parameters are positive. The effects of Growth hormone replacement therapy on various aspects of learning and memory have received less attention but are clearly of the utmost importance.

Rats, which are homozygous for the Dw-4 mutation (‘dwarf’), do not exhibit the normal increase in Growth hormone at 4 weeks of age, during a time at which, in rats, Growth hormone levels normally rise. In this paper, this model was used to mimic early onset or childhood Growth hormone deficiency. There were four groups that were compared as follows:

  • Untreated Dw-4 mutation rats (early onset Growth hormone deficiency); 
  • rats treated from 4 to 14 weeks (replete in childhood but deficient in adults (adult onset Growth hormone deficiency;
  • rats treated from 4 weeks and thereafter (Growth hormone replete) and iv) rats heterozygous for the mutation (controls).

Using a water maze test to assess spatial learning ability at 8 and 18 months, it was shown that the early onset Growth hormone-deficient group had poor spatial learning compared to the other groups. The suggestion is made that Growth hormone deficiency during adolescence has negative effects on learning and memory, and that this effect can be reversed in rats by Growth hormone supplementation.

Kwak et al. have shown that in hypophysectomised female Sprague–Dawley rats given Growth hormone, not only was somatic growth enhanced, as predicted, but that cognitive function as assessed by the Morris water maze test was significantly better in the Growth hormone-treated animals, suggesting that Growth hormone improved the acquisition of spatial memory. Growth hormone has also been shown to accelerate recovery of motor function and improve spatial memory in the same water maze test when given to a group of rats in which stroke induction had been carried out.

In humans, there are clear deficiencies in cognitive functions in Growth hormone deficiency patients. Thus, impaired hippocampal/mesial temporal function has been shown in adulthood of patients with childhood onset Growth hormone deficiency. This disturbance is also greater in childhood onset Growth hormone deficiency than adult onset Growth hormone deficiency. In younger patients with Growth hormone deficiency, Growth hormone treatment has been associated with improvements in measures of memory and attention. Factors associated with an improvement depend on the extent of cognitive impairment at baseline, the dose of Growth hormone administered and to some extent the age at onset of Growth hormone deficiency. There are differences in verbal memory of patients with childhood onset Growth hormone deficiency when compared with age-matched controls. Whether this, as opposed to somatic development, is benefited by Growth hormone replacement in humans is unclear. Certainly, there is continued maturation of fronto-temporal connections in the second and third decades of life.

We have looked at the effects of Growth hormone on cognitive function in elderly patients with adult onset Growth hormone deficiency and, using a battery of psychometric measures, we assessed cognition and mood. There were improvements at 6 months from baseline in the Growth hormone-treated group for the digit-learning test. There were also small improvements in cognition, but these differences between Growth hormone and the control groups were in part due to a decline in performance in the placebo group, as well as improvement in the Growth hormone-treated group. At the 12-month assessment, no significant benefits of Growth hormone were found. This may relate in part to the small sample size (34 patients).

The brain in man continues to mature and develop in young adulthood. There is evidence of maturation of neural connections in the second and third decades of life; GH and insulin-like growth factor 1 levels normally rise to a peak at around the period of late adolescence. Whether these are related remains unanswered, but the current study certainly suggests the possibility of an important interaction.

Further work clearly needs to be done, particularly in man. Adequate numbers of patients need to be studied, and there are problems with complicating factors such as past radiotherapy which may itself have adverse effects on cognitive function which are not currently clearly delineated. Thus, any studies on radiotherapy effects on cognitive function need to correct for Growth hormone deficiency.

The suggestion that there is an important period of childhood during which, if Growth hormone deficiency occurs, there is a significant defect in cognitive development which may be reversible with Growth hormone therapy is important. Long-term effects on memory should therefore be added to the list of benefits of childhood Growth hormone treatment, as this may be used as an incentive for compliance.

April 25, 2014
Steroid Cycles for Beginners

If you’ve never supplemented with anabolic steroids before knowing what to do can seem like an overwhelming task. To begin there’s a massive amount of information available, not to mention numerous steroid related message boards. When you look at all the information and read all the varying opinions, more times than not the individual is left more confused than when he first began his education. Go to one message board and you’ll find “the experts” say do 1, 2 and 3 followed by A, B and C. Go the next message board and you’ll find others who say you should start with A, B and C and only add in 1, 2 and 3 if you’re really serious about your pursuit. Not only can this talk be confusing, for many would be performance enhancers it’s annoying.

Let’s be clear, very clear right from the start. Anabolic steroids are not magical. When we supplement with anabolic steroids the rules of nutrition do not go flying out the window, the basic principles of training are not lost to the wind. The basic idea behind supplemental anabolic steroid use is not to create a magical solution but to take what you’re already doing correctly and to enhance it. Put simply, you’re going to take what you’re already doing right and now you’re simply going to do it a little better. Anabolic steroids are not the answer, they encompass part of the overall solution that includes sound nutrition, proper training and a well-thought out plan one holds to; as it pertains to the steroids themselves, in the end it all boils down to personal education.

Before you begin your journey into the anabolic world there are some important steps you need to take. First and foremost you must educate yourself on the hormones. Know what it is you’re going to be putting into your body; know not only what the benefits are but what the possible adverse effects may be and know how to combat them. Once this is under control your next order of business is going to be ensuring the steroids you’re considering purchasing are of a high quality nature. The last thing you want is a contaminated product and even if it’s clean you certainly don’t want an under-dosed product or one that’s counterfeit. As your education becomes more sound and you have access to assured quality products there are some important questions you need to answer:

  • Are you a healthy adult male?
  • Have you spent some time building a solid foundation?
  • Are you willing to accept any consequences that may fall your way should you supplement irresponsibly?

If you can answer “Yes” to these questions and if you have fulfilled the prior two requirements, personal education and ensuring a quality supplier is available then you’re ready to begin. As it pertains to your personal education no one is implying you need to be a steroid expert, you simply need a solid grasp on what you’re doing. Anabolic steroids are very powerful hormones and they demand respect. They are not as complicated to understand as many tend to make them out to be but this does not take away from the respect they demand.

For the true beginner to anabolic steroid supplementation for the purpose of performance enhancement, the initial cycle will more than likely be one of the simplest cycles of all. While it will be simple it is by no means weak; in-fact, for many performance enhancers such a cycle will be all they ever need. There will further only be 3 items you need; two anabolic steroids and 1 SERM. Of these 3 items two will be essential, one of the steroids and the one SERM with the second anabolic steroid being optional; the optional steroid will be the oral steroid included in the cycle. It is a 12 week plan followed by a 3 week post cycle recovery with the total plan taking 17 weeks and is as follows:


Week Testosterone-Enanthate  Dianabol       Nolvadex
1                  500mg                           25mg Every Day
2                  500mg                           25mg Every Day
3                  500mg                           25mg Every Day
4                  500mg                           25mg Every Day
5                  500mg                           25mg Every Day
6                  500mg                           25mg Every Day
7                  500mg
8                  500mg
9                  500mg
10                500mg
11                500mg
12                500mg
13
14
15               40mg Every Day
16               40mg Every Day
17               20mg Every Day

The first thing you may have noticed is that week’s 13 and 14 do not have anything in them and that was done with purpose. The above cycle is based and built around Testosterone-Enanthate; as such you will need to wait a couple weeks to allow the hormone to clear your system before you begin Nolvadex therapy. You could even wait a total of 3 weeks to reach this point but you will want to start your Nolvadex therapy no later than 3 weeks after your last Testosterone-Enanthate injection.

During this cycle you will notice the gains start rapidly, largely due to the Dianabol and begin to slow down as you progress, especially the last few weeks. This does not mean we stop the cycle early as you need to continue in-order to allow your body to become accustomed to the gains made, if you are going to keep any of them once the cycle has been discontinued. Let’s discuss each compound briefly:

Testosterone-Enanthate: If Testosterone-Enanthate is not available you can substitute Testosterone-Cypionate in its place as the two are virtually identical. For this cycle you will administer the hormone on one of two scheduled plans; one 500mg injection once per week or two 250mg injections twice per week, say Monday and Thursday. In either case the job will be done with the second option be optimal but only slightly. This will be the basis of your cycle and will give you the greatest benefits of all.

Dianabol: As you will be taking this every day the first 6 weeks you can take the entire dose all at once or you can split it into two doses per day for optimal results; say 15mg in the morning and 10mg at night or vice versa. Through the use of Dianabol you will add mass and strength very quickly as the Testosterone builds in your system.

Nolvadex: When supplementing with anabolic steroids our natural testosterone production is suppressed. Even though we are supplementing with exogenous testosterone our body will not be making the testosterone it needs. Once the cycle is over it’s time to stimulate our natural production and Nolvadex can do just that. By stimulating the release of LH and FSH our testicles will begin producing again. No, the PCT period in-which we supplement with Nolvadex will not bring our levels all the way back to normal; there is no PCT plan that can do this but it will lead us to that end much faster than without.

It must be noted possible side-effects such as Gynecomastia, water retention, high blood pressure and high cholesterol are all a possibility with this cycle as both Testosterone and Dianabol aromatize and cause a buildup in estrogen. If you’re nipples begin to get sore while on cycle you might try supplementing with 10mg of Nolvadex per day. If this does not work you are going to need an Aromatase Inhibitor such as Arimidex or Letrozole; 0.5mg every other day of either should suffice. Further, if you keep your diet clean you will largely protect from water retention; some will occur if you are really trying to bulk but limit your excess calories only to what you absolutely need and avoid overeating carbohydrates. Further, keeping your diet clean is also good for your blood pressure and cholesterol; moreover, consuming plenty of Omega-3 Fatty Acids can greatly serve you here.

April 17, 2014
Testosterone Suspension and Testosterone Base. Testosterone No Ester

Testosterone is the undisputed king of steroids mainly because it is safe, elicits rapid mass and strength gains while maintaining libido, a sense of well being and energy. It’s not uncommon for a first time user to gain 15-20lbs of LBM in a standard Testosterone cycle. Pure Testosterone comes in a water based aqueous form (Suspension) and also in a solvent/oil based form (Test Base).

Suspensions have tiny particles that are visible with the naked eye. If left on the shelf for a few days many times the particles will sink to the bottom leaving the clear solvents and water on the top. Depending on the manufacturer, particle sizes vary meaning some Suspension preparations can clog a 22 gauge needle. Ultra micronized Suspension can pass through a 25 gauge needle making injections more comfortable. Shake the suspension preparation vigorously before injecting.

Testosterone suspension is the most potent form of testosterone because it does not possess an ester. Esters are calculated into the steroid weight therefore esterfied steroids are not a true mg for mg of free hormone. 100mg of suspension is 100mg of free hormone! Enanthate in a solution is only 72mg of free hormone per 100mg. You can see that Suspension is the true king steroid. However because there is no ester many users will inject suspension everyday or even multiple times per day. This is usually reason enough for most people to reject using suspension but it gets worse. Usually suspension is quite painful as well. Combine every day injections with significant pain and most users simply pass on trying suspension at all. Some new science now demonstrates that everyday and even every other day injections are not necessary with Testosterone Suspension.

What is the real half life of Testosterone Suspension?

There is no classic half life of aqueous Testosterone Suspension due to the nature of the various suspension particle sizes and the non existence of an ester. In other words we don’t see the same types of decay rates with blood androgen levels in non esterfied preparations that are seen in esterfied preparations. However in March of 2011 there was a pharmacokinetics study done in horses that reported a median terminal half-life of 39 hours with aqueous Testosterone Suspension. The disposition of testosterone from this formulation was characterized by an initial, rapid absorption phase followed by a much more variable secondary absorption phase. There were at least two plasma testosterone concentration peaks. The first peak is almost immediate and the second peak is a whopping 7 days later on average according to the chart in the full study. The study indicates that the initial peak is from the Testosterone formulation solution and the following peak(s) from the solid material in the suspension.

Basically the solution almost immediately hits the blood stream when injected and then a few days later the solid particles are slowly absorbed by the body causing other peaks in testosterone blood androgen levels.

So how often should you administer Suspension?

Based on this science, injecting Suspension every other day or even every three days will maintain high blood androgen levels. The king of steroids has had a time release delay built into it all along and we have the data to prove it. 100mg every other day would be a good starting dose for newer male users. More advanced male users could easily double that dose for very rapid and pronounced LBM gains. Suspension is moderately estrogenic and that effect will be dose dependant. The more you administer the more likely aromatase activity will occur. I would use Nolvadex to lower estrogenic side effects or an aromatase inhibitor.

Sample 8 week Suspension cycle

Monday  - 150mg Suspension/20mg Nolvadex
Tuesday - 20mg Nolvadex
Wednesday  - 150mg Suspension/20mg Nolvadex
Thursday -   20mg Nolvadex
Friday -  150mg Suspension/20mg Nolvadex
Saturday -  20mg Nolvadex
Sunday -  20mg Nolvadex

Nolvadex is used to keep lipids positively influenced for those concerned with cardiovascular health. I have opted for an injection schedule of only three times per week to allow for comfort and because a more frequent schedule is not needed.

This cycle should produce rapid increases in strength and mass. I would use this cycle during a bulking phase. A more adventuresome user could stack a strong oral like Dianabol or Anadrol with the above cycle at 50mg daily producing an amazing and rapid increase in size and strength if nutrition, training and recovery are dialed in.

Testosterone Base~Oil/Solvent Based

Testosterone Base is 100% pure testosterone similar to aqueous Testosterone Suspension however Test Base is technically a solution not a suspension. Test Base contains no visible Testosterone crystals because they are in an oil and solvent solution NOT water. There are no crystals to slowly absorb into the injection site. Therefore when you inject Test Base there is a very rapid increase in blood Testosterone levels that falls off faster than standard aqueous Testosterone suspension. Test Base packs a big instant wallop when injected and is arguably the fastest Testosterone product available today. Another advantage of Test Base is you may use very small gauge needles to inject it. There are no crystals in Test Base to clog the needle so administering with an insulin syringe is an option. Test Base is ideal pre training or for power lifting or strength sports. I recommend Test Base to be administered two hours pre-training to provide increased aggression and power

April 11, 2014
Halotestin is a good compound for use by athletes

Unfortunately for bodybuilders, its muscle-building attributes are not as effective. Halotestin doesn’t convert to estrogen in the body, but it is toxic to the liver, so small doses are recommended.

Halotestin is the Upjohn brand name for the steroid fluoxymesterone. Structurally fluoxymesterone is a derivative of testosterone, differing from our base androgen by three structural alterations (specifically l7alpha-methyl, 11 beta-hydroxy and 9-fluoro group additions). The result is a potent oral anabolic steroid that exhibits extremely strong androgenic properties. This has a lot to due with the fact that it is derived from testosterone, and as such shares important similarities to this hormone. Most importantly, like testosterone, Halotestin appears to be a good substrate for the 5-alpha reductase enzyme. This is evidenced by the fact that a large number of its metabolites are found to be 5-alpha reduced androgens, which coupled with its outward androgenic nature, suggests it is converting to a much more active anabolic steroid in androgen responsive target tissues such as the skin, scalp and prostate.

The 11 beta-hydroxyl group also inhibits aromatization, making estrogen production impossible with this steroid. Estrogenic side effects such as water retention, fat fain and gynecomastia are therefore not a concern when taking this compound. Strong androgenic side effects are to be expected though, and in many cases are unavoidable. Oily skin and acne a very common for instance, at times requiring sensitive individuals to seek some form of topical or even prescription drug treatment to keep it under control. Hair loss is an additional worry, making Halotestin a poor choice for those with an existing condition. Aggression may also become very pronounced with this drug. This effect is often desired by users looking to “harness” this in order to increase the intensity of workouts or a competition. Clearly Halotestin is a strong androgen, and definitely one female athletes should stay away from. Masculinizing side effects can be intense, and may occur very rapidly with this substance. Even women daring enough to take Dianabol should think twice about this compound, as virilization symptoms are most often permanent.

Although Halotestin appears to be more androgenic than testosterone, the anabolic effect of it is not very strong. This makes it a great strength drug, but not the best for gaining serious muscle mass. The predominant effect seen when taking Halotestin is a harder, more dense look to the muscles without a notable size increase. It is therefore very useful for athletes in weight-restricted sports like wrestling, powerlifting and boxing. The strength gained from each cycle will not be accompanied by a great weight increase, allowing most competitors to stay within a specified weight range. Halotestin also makes an excellent drug for bodybuilding contest preparation. When the competitor has an acceptably low body fat percentage, the strong androgen level (in absence of excess estrogen) can elicit an extremely hard and defined (“ripped”) look to the muscles. The shift in androgen/estrogen ratio additionally seems to bring about a state in which the body may be more inclined to burn off excess fat and prevent new fat storage. The “hardening” effect of Halotestin would therefore be somewhat similar to that seen with trenbolone, although it will be without the same level of mass gain. Clearly non-aromatizing androgens such as Halotestin and trenbolone can play an important role during contest preparations.

The main concern with Halotestin is that it can be a very toxic drug. This is due to the fact that fluoxymesterone is a 17 alpha alkylated compound, its structure altered to survive oral administration. l7alpha alkylation can be very harsh to the liver. The possibility of damage is therefore a legitimate concern with Halotestin, especially when used at higher doses or for prolonged periods of time. The total daily dosage is likewise best kept in the range of 20-40mg, used for no longer than 8 weeks. After which an equally long break (at a minimum) should be taken from all c17-AA orals. One should also resist the temptation to stack this drug with other alkylated orals if possible, and instead opt for orals without this alteration or esterified injectable compounds (which will not add to the strain on the liver).

In cutting phases a mild anabolic such as Deca-Durabolin or Equipoise might prove to be a good addition, as both provide good anabolic effect without excessive estrogen buildup. Here Halotestin will provide a well needed androgenic component, helping to promote a more solid and defined gain in muscle mass than obtained with an anabolic alone. Perhaps Primobolan Depot would even be a better choice, as with such a combination there is no buildup of estrogen (and likewise even less worry of water and fat retention). For mass we could alternately use an injectable testosterone. A mix of 400-800mg Testosterone enanthate and 20-30mg Halotestin for example, should prove to be an exceptional stack for strength and muscle gain. This however would be accompanied by a more significant level of side effects, both compounds exhibiting strong androgenic activity in the body.

Halotestin also seem to depress endogenous testosterone levels rather quickly with use, despite its complete lack of estrogen conversion. One therefore should consider ancillary drug use at the conclusion of each cycle in order to help restore the normal release of androgens in the body. Using a combination of HCG and Clomid/Nolvadex is of course the best option, the two drugs working well together to restore normal hormonal functioning. Although estrogen is not a problem with Halotestin, the use of an anti-estrogen such as Nolvadex or Clomid is still indicated when discontinuing a cycle. Since HCG stimulates aromatase activity in the Leydig’s cells, here Nolvadex/Clomid help by blocking the activity of any excess estrogen that may be produced. Afterward they will also block the inhibitory effect of endogenous estrogens on the hypothalamus, stimulating the enhanced release of gonadotropins and supporting the normal biosynthesis of testosterone.